My research focuses on the fundamental and applied aspects of nanomechanics, biomolecular interactions, soft materials, and nano-microfabrication for nanoparticle biosensing and unusual electronic system development, with an emphasis on bio-interfaced translational nanoengineering. In this talk, I will discuss about recent research works on soft, wearable and implantable electronics which include biomimetic materials, mechanics designs, and system integration, aiming for advancing human healthcare and human-machine interfaces. Specifically, I will talk about some examples of wearable electronics for ergonomic human-machine interfaces, cardiovascular monitoring, and hypertension management.