Chronic and acute stress monitoring byelectrophysiological signals from adrenal gland
Sung Hyuk Sunwoo, Ju Seung Lee, SungJun Bae, Yiel Jae Shin, Chang Seong Kim, Soo Yeon Joo, Hong Sang Choi, Minah Suh, Soo Wan Kim, Young Jin Choi, and Tae-il Kim
We present electrophysiological (EP) signals correlated with cellular cell activities in the adrenal cortex and medulla using an adrenal gland implantable flexible EP probe. With such a probe, we could observe the EP signals from the adrenal cortex and medulla in response to various stress stimuli, such as enhanced hormone activity with adrenocorticotropic hormone, a biomarker for chronic stress response, and an actual stress environment, like a forced swimming test. This technique could be useful to continuously monitor the elevation of cortisol level, a useful indicator of chronic stress that potentially causes various diseases.